29 articles - From Friday Oct 21 2022 to Friday Oct 28 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Rheumatology (Oxford) |
Assessment and diagnosis of the acute hot joint: A systematic review and meta-analysis. Our review demonstrates many single tests, individually with diagnostic utility but suboptimal accuracy for exclusion of native joint infection. A combination of several tests +/- stratification score is required to optimise rapid assessment of the hot joint. |
COVID-19 vaccination in systemic lupus erythematosus: a systematic review for effectiveness, immunogenicity, flares and acceptance. Post-vaccine COVID-19 infection, severe flares and adverse events were infrequent and pooled seropositivity and acceptance were high with significant heterogeneity. These results may inform shared-decision making on vaccination during the ongoing COVID-19 pandemic. Protocol registration PROSPERO; CRD42021233366. |
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
American College of Rheumatology/EULAR remission criteria for rheumatoid arthritis: 2022 revision. Using the Boolean 2.0 criteria classifies, more patients as achieving remission and increases the agreement with index-based remission criteria without jeopardising predictive value for radiographic or functional outcomes. This revised Boolean definition and the previously provisionally endorsed index-based criteria were endorsed by ACR and EULAR. |
| Arthritis Care Res (Hoboken) |
Female gender and age are associated to unfavorable response to TNFa inhibitors in patients with axial Spondyloarthritis: results of statistical and artificial intelligence-based data analyses of a national multicentric prospective registry. In this national multicentric registry, female gender was associated with less response to a first line TNFi by the second year of follow-up. A higher age at the start of the TNFi was the main factor associated to unfavorable response to TNFi. |
Identification of Symptoms Phenotypes of Hand Osteoarthritis using Hierarchical Clustering: Results from the DIGICOD Cohort. The identification of distinct clinical clusters based on HOA cardinal symptoms suggests previously undescribed subtypes of this condition warranting further study of biological characteristics of such clusters and opening a path toward phenotype-based personalized medicine in HOA. |
Predictors of Patient and Physician Assessments of Gout Control. For both patients and physicians, absence of gout flares and serum urate levels at the treatment target predict assessment of gout control. However, discordance between patients and physicians in their assessment of disease control is not uncommon, with recent gout flares and tophus predicting lower scores by physicians than patients. |
| Arthritis Res Ther |
Methotrexate improves endothelial function in early rheumatoid arthritis patients after 3 months of treatment. MTX has a positive effect on Tang, sVCAM-1, EPCs and EMPs in RA. Restoration of imbalance between CD28 |
| Arthritis Rheumatol |
American College of Rheumatology/EULAR Remission Criteria for Rheumatoid Arthritis: 2022 Revision. Using the Boolean 2.0 criteria classifies more patients as achieving remission and increases the agreement with index-based remission criteria without jeopardizing predictive value for radiographic or functional outcomes. This revised Boolean definition and the previously provisionally endorsed index-based criteria were endorsed by ACR and EULAR. |
Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout. Gout risk variants also harbor risk for earlier age at onset and tophaceous disease in European and Polynesian men. Our findings suggest that earlier gout onset involves the accumulation of gout risk alleles in men but perhaps not women, and that this genetic risk is shared across multiple ancestral groups. |
Autoreactive plasmablasts after B cell depletion with rituximab and relapses in ANCA-associated vasculitis. The composition of autoreactive B cell pool varies significantly following rituximab treatment in AAV, and early plasmablast enrichment within the autoreactive pool is associated with future relapses. |
Biophysical phenotyping of circulating immune cells identifies a distinct monocyte-driven signature in systemic sclerosis. Changes in biophysical properties of circulating immune cells reflect their pathologic activation in SSc and are associated with clinical outcomes. As a high throughput approach that requires minimal preparations, RT-FDC-based biophysical phenotyping of monocytes can serve as a tool for evaluation and risk stratification of patients with SSc. |
Functional genomics in primary T cells and monocytes identifies mechanisms by which genetic susceptibility loci influence systemic sclerosis risk. Our study reveals potential causal genes for SSc-associated loci, some of them acting in a cell type specific manner, suggesting novel biological mechanisms that might mediate SSc pathogenesis. |
Three Distinct Transcriptional Profiles of Monocytes Associate with Disease Activity in Scleroderma Patients. We are the first to show that transcriptional signature of CM and NCM can be used to unbiasedly stratify SSc patients and correlate with disease activity outcome measures. |
| Rheumatology (Oxford) |
Efficacy and safety of risankizumab for active psoriatic arthritis: 52-week results from the KEEPsAKE 1 study. In patients with active PsA who were csDMARD-IR, continuous risankizumab treatment demonstrated robust long-term efficacy and was well tolerated through 52 |
External validation of the alternative Ankylosing Spondylitis Disease Activity Score in three randomised clinical trials of ixekizumab. altASDAS was truthful and discriminative in an external cohort and as such has been fully validated to be used in cases when PGA is unavailable. |
Inactivated SARS-CoV-2 vaccine does not increase the risk of relapse in patients with clinically inactive adult-onset Still's disease. Increased disease activity or relapse following vaccination with inactivated SARS-CoV-2 were rare in patients with inactive AOSD. Local and systemic adverse reactions were found to be mild and self-limiting. These safety profiles of inactivated SARS-CoV-2 vaccines in patients with AOSD may assist in eliminating vaccine hesitancy and increase the vaccination rate against SARS-CoV-2. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Ann Rheum Dis |
Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis. New evidence supports the efficacy and safety of TNFi (originators/biosimilars) and IL-17i in r-axSpA and nr-axSpA, while IL-23i failed to show relevant effects. Observational studies are needed to confirm long-term IL-17i safety. Prospero registration number CRD42021257588. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Rheumatology (Oxford) |
Letters to the editors and authors’ replies
| Arthritis Res Ther |
Sex-specific exposures and sex-combined outcomes in two-sample Mendelian randomization may mislead the causal inference. We suggested the author add the possible biases due to the issue in the limitations. With problems mentioned above, we recommend solutions to make this article more perfect. |
| Arthritis Rheumatol |